Translational Research Facility (TRF)

Our $84 million state-of-the-art Translational Research Facility (TRF) was completed in October 2015. The TRF co-locates research, clinical and technological platforms to facilitate the collaboration of our researchers and clinical partners to accelerate and coordinate the translation of scientific breakthroughs.
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Bioinformatics

Bioinformatics is an interdisciplinary field that develops and improves on methods for storing, retrieving, organising and analysing biological data. A major activity in bioinformatics is to develop software tools to comprehend complex biological systems.

Capabilities
  • Differential Gene Expression – Statistical analysis of differential gene expression from transcriptomics data (microarray, RNAseq)
  • Variant Identification – Identification of genetic variants (SNPs and InDels) from large scale genomics data
  • Methylation and ChIPseq – Exploration of epigenetics and post-transcriptional modifications of the genome and its expression
  • De-novo assembly – In silico assembly of transcriptomics or genomics data from non-model organisms

The platform also provides access to the IPA (Ingenuity Pathway Analysis) and Metacore (GeneGo) software via a hot desk for its collaborators.

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Cell Therapies

Cell Therapies
The Cell Therapies Platform hosts a biological Isolator that provides a sterile, fully contained environment suitable for the processing of human cells and tissue. This facility has been established to boost the clinical development of human cell-based therapies. 

The CTP provides a flexible, cost effective alternative to traditional cell therapy manufacturing facilities. It is available to researchers within and outside the MHTP seeking to translate their human cell and tissue-based therapies to the clinic.

Contact

  • Prof Graham Jenkin, Ritchie Centre, Hudson Institute, Department of Obstetrics and Gynaecology, Monash University, Ph. +61 3 8572 2801, graham.jenkin@monash.edu

 

 

Flow Cytometry

Flow Cytometry
The Flow Cytometry Facility uses sophisticated instruments for cellular and particle analysis based upon the use of fluorescent probes and markers. Flow cytometers can be used for investigating cellular makeup, enabling detailed analysis of biological activity and function and for isolating rare cell populations for further studies.  The facility currently operates one high speed sorter and two cell analysers and provides the following services on a fee-for-service model:
  • Cell sorting
  • Cell analysis
  • Training for independent use of cell analysers
  • Advice on experimental design and data analysis

Contact

  • Dr James Ngui, Senior Scientist, Monash Pathology, Ph. + 61 3 9594 3611, flow.mmc@monash.edu
  • Ms Jeanne Butler, Research Scientist, Monash University

Histology

The Hudson Institute's Histology Facility was established in 1999 to support the needs of researchers and students at the Institute. The Facility also provides services for the Monash Health Translation Precinct (MHTP) and external clients. Our aim is to provide high quality, reliable and cost effective histological serviceHistology involves the study of the microscopic anatomy of cells and tissues. Tissues are carefully processed, sectioned and stained revealing delicate morphological features that can indicate health or disease for research, education or clinical studies.  The Histology Platform has two service models:

  • a full “Professional” end-to-end service provided by specialist staff
  • a "Do it Yourself" service providing access to laboratory facilities, specialist equipment and consumables.

In addition, the experienced Histology team can provide advice, training and research assistance in:

  • Dissection
  • Cassetting
  • Processing – to resin or paraffin
  • Cutting – fresh, resin or paraffin sections
  • Staining and coverslipping -automated or manual
  • Immunohistochemistry – automated utilising the Dako Autostainer
  • Micro Tissue array slide supply – creation of micro tissue arrays to suit your needs. We can create the multi block for you and provide sections for use as control tissue
  • Slide scanning
  • Digital photography, basic fluorescence and polarization

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Mass Spectrometry

Mass Spectrometry
The Mass Spectrometry Facility houses cutting-edge mass spectrometry and proteomics technologies for the study of protein structure and function, and their relationship to human disease.  The facility can provide:
  • Based upon a collaborative model:
    • Consultation to researchers interested in or engaged in biomarker identification, including basic protein identification, fractionation and analysis
    • Proteomic analyses for discovery studies, using in-gel and gel-free technologies
    • Design and development of Mass spectrometry-based research diagnostics and/or ELISA assays
  • Based upon a fee-for-service model:
    • A range of NATA certified assays for steroids, metanephrines, vitamins and drugs
    • Assay service for research groups

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Medical Genomics

 
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Medical Genomics
The Medical Genomics Facility provides a comprehensive range of technologies to analyse DNA and RNA, to determine it’s structure and function and it’s role in health and disease.

We provide a broad range of specialist genomic services based upon a fee-for-service model including:

  • Sanger Sequencing (ISO 15189 NATA accredited)
  • Quantitative real-time PCR
  • Fragment Analysis
  • High Content Screening
  • Microarray
  • Next Generation Sequencing
  • Fluidigm single cell genomics
  • Cell line identification
  • Bioinformatics

Contact
Ms Vivien Vasic, MHTP Medical Genomics Facility Manager
Dr Trevor Wilson, Next Generation Sequencing Manager
Ms Jodee Gould, Microarray Manager
Hudson Institute of Medical Research
medicalgenomics@monash.edu
Ph. +61 3 8572 2770

Micro Imaging

The Micro Imaging Facility specialises in optical, fluorescence 4D, live cell and statistical microscopy methodologies, as well as image and data informatics to understand cellular and molecular processes.  MMI charges an annual subscription fee to cover training and instrument access for internal users.  Micro Imaging provides:

 

  • Experimental design and troubleshooting
  • Instrumentation
  • Training
  • Research collaboration
  • Project development

 

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Monash Biobank

The Monash Biobank is a recent initiative established by Monash Health’s Pathology department to support translational research through procurement of human samples.

Services
  • Assistance with HREC application
  • Sample collection and processing following SOP or researcher’s protocol (for prospective and specific studies)
  • Sample storage and data collection
  • Archived tissue retrieval and selection
  • Sectioning and Tissue Micro Arrays to suit project requirements
  • Immunohistochemistry
  • Digital imaging


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